492 SERUM-FREE CONDITION STIMULATES REDIFFERENTIATION OF FULLY DEDIFFERENTIATED COSTAL CHONDROCYTES IN PELLET CULTURE
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چکیده
منابع مشابه
Down-Regulation of Transglutaminase 2 Stimulates Redifferentiation of Dedifferentiated Chondrocytes through Enhancing Glucose Metabolism
Expansion of chondrocytes for repair of articular cartilage can lead to dedifferentiation, making it difficult to obtain a sufficient quantity of chondrocytes. Although previous studies have suggested that culture in a three-dimensional environment induces redifferentiation of dedifferentiated chondrocytes, its underlying mechanisms are still poorly understood in terms of metabolism compared wi...
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Although pellet culture and encapsulation of chondrocytes into gel-like biomaterials have lead to major advances in cartilage tissue engineering, a quantitative comparative characterization of cellular differentiation behavior during those cultivation procedures has not yet been performed. Our study therefore aimed at answering the following question: is the redifferentiation pathway of chondro...
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Introduction Synovial joints are susceptible to cartilage injury and degeneration. Treatment of articular cartilage damage is a challenge because this tissue is unable to regenerate and repair itself. Tissue-engineered cartilage has been successfully implanted to treat osteoarthritic human knees; however, efforts to reduce inflammation and tissue degradation of implanted cartilage are not well ...
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Given the difficulties in accessing articular cartilage as a source of chondrocytes to be used in fabricating cartilage constructs, alternative sources are required. The present study examined chondrocytes from costal cartilage for their suitability in cartilage tissue engineering. Chondrocytes isolated from rat knee and rib hyaline cartilage were separately mixed with alginate and placed in a ...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2008
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(08)60532-4